T-SPOT® Discovery

About the kit

The T-SPOT Discovery SARS-CoV-2 kit has been developed to aid in the investigation of the T cell response to SARS-CoV-2 infection. The kit uses a modified ELISPOT assay where samples prepared from peripheral blood are stimulated in vitro by peptide pools from SARS-CoV-2. This re-stimulation allows SARS-CoV-2 specific T cells to be enumerated.

The kit builds on Oxford Immunotec’s experience with TB diagnosis and the assessment of immune response to CMV in transplant patients, to apply the Company’s established, proprietary T-SPOT technology to the fight against COVID-19. While serology is able to detect antibodies to SARS-CoV-2 in the blood of some individuals after infection, little is currently known about how this confers immunity to COVID-19. The T-SPOT technology goes further than simple serology by interrogating the immune system’s T cell response and will enable research into the measurement of the strength of that response to SARS-CoV-2. The strength of this response may be linked to protection from reinfection.

Previous webinar 
Title: The role of cell-mediated immunity in immune responses to SARS-CoV-2 infection
Date: Wednesday 15th July, 14:00 – 15:00 (BST)
Presenter: Ruth Brignall, PhD. Medical Science Liaison from Oxford Immunotec

Recording coming soon

The T-SPOT technology

The T-SPOT technology is a proven technology, approved for clinical use to detect TB infection in over 60 countries including the US, China, Japan and Europe. With over 20 million clinical tests manufactured since release, the T-SPOT technology:

  • Uses a standardized sample prepared from peripheral blood which:
    • Reduces the influence of factors which might affect results, such as other treatments
    • Standardizes cell numbers in the test to normalize for cell number variations between samples
  • Allows the number of responding T cells to be enumerated for a more precise assessment of the T cell response
  • Is able to maintain performance, even in samples from immunosuppressed individuals
  • Can be run in high volume labs enabling large testing programs to be rolled out

The T-SPOT Discovery SARS-CoV-2 kit is for Research Use Only. Not for use in diagnostic procedures.

Automation solutions using T-Cell Select TM

The T-SPOT technology can also be automated using the T-Cell Select reagent kit. Automation solutions are available for low, medium and high throughput settings. Not all products and reagents are available in all countries, please contact us for details on availability in your country.

Oxford Immunotec Global PLC is a global, high-growth diagnostics company.  We bring energy and invention to a world in need of diagnostic truth. Our leading product, the T-SPOT.TB test, is used for diagnosing infection with tuberculosis, the world’s largest cause of death from infectious disease. The T-SPOT.TB test has been approved for sale in over 60 countries, including the United States, where it has received pre-market approval from the Food and Drug Administration, Europe, where it has obtained a CE mark, as well as Japan and China.
The Company is headquartered near Oxford, U.K. and in Marlborough, MA.