immunocompromised T-SPOT.TB test females

Reliable in the immunocompromised

Who are the immunocompromised?

Many diagnosed with an underlying condition don’t realize that they are immunocompromised.1 Those with compromised immune systems face a higher risk of contracting tuberculosis (TB) and a higher risk of latent tuberculosis infection (LTBI) becoming active. The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) has published the following list of people at high-risk for developing active TB disease once infected with Mycobacterium tuberculosis (MTB):2,3

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Persons living with diabetes

77 million people live with diabetes in APAC5

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Persons living with inflammatory bowel disease (IBD)

6.8 million person are estimated to live with inflammatory bowel disease globally6

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Persons living with rheumatoid arthritis

Upwards of 78 million (1% of global population) is living with rheumatoid arthritis7

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Persons living with HIV/AIDS

5.8 million people living with HIV/AIDS in APAC8

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Persons living with chronic kidney disease

700 million estimated cases of Chronic Kidney Disease (CKD) globally9

  • Persons who are receiving immunosuppressive therapy
  • Persons who were recently infected with MTB (within the past 2 years)
  • Persons with a history of untreated or inadequately treated active TB disease
  • Persons living with leukemia, lymphoma or cancer of the head, neck or lung
  • Persons who have had a gastrectomy or jejunoileal bypass
  • Persons who weigh less than 90% of their ideal body weight
  • Persons who smoke cigarettes or abuse drugs or alcohol
  • Populations defined locally as having an increased incidence of active TB disease, possibly including medically underserved or low-income populations

The T-SPOT.TB is the only IGRA, or TB blood test, without a warning or limitation in their package insert for screening immunocompromised individuals10,11

The reliability of the T-SPOT.TB test design, which includes washing and standardizing the number of cells in each patient specimen, is supported by clinical data obtained even in challenging patient populations. The cell enumeration technology in the proprietary T-SPOT.TB test therefore will allow clinicians to confidently screen and detect TB infection.14

Patient populations can vary, but your TB blood test results should not. The T-SPOT.TB test is accurate across all patient populations. In fact, the T-SPOT.TB test is the only TB blood test without a warning in their package insert against use the immunocompromised population.

  1. Accurate across patient populations14

    • Immunocompromised
    • BCG-vaccinated
  2. Highest sensitivity and specificity compared to other IGRAs

    • Sensitivity: 98.8%
    • Specificity: 100%
  3. US-FDA approved borderline zone provides increased test resolution for results around the cut-off point16,17

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T-SPOT.TB test

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