Many diagnosed with an underlying condition don’t realize that they are immunocompromised.1 Those with compromised immune systems face a higher risk of contracting tuberculosis
(TB) and a higher risk of latent tuberculosis infection (LTBI) becoming active. The
World Health Organization (WHO) and
Centers for Disease Control and Prevention (CDC)
has published the following list of people at high-risk for developing active TB disease once infected with Mycobacterium tuberculosis (MTB):2,3
Persons living with diabetes
77 million people live with diabetes in APAC5
Persons living with inflammatory bowel disease (IBD)
6.8 million person are estimated to live with inflammatory bowel disease globally6
Persons living with rheumatoid arthritis
Upwards of 78 million (1% of global population) is living with rheumatoid arthritis7
Persons living with HIV/AIDS
5.8 million people living with HIV/AIDS in APAC8
Persons living with chronic kidney disease
700 million estimated cases of Chronic Kidney Disease (CKD) globally9
Persons who are receiving immunosuppressive therapy
Persons who were recently infected with MTB (within the past 2 years)
Persons with a history of untreated or inadequately treated active TB disease
Persons living with leukemia, lymphoma or cancer of the head, neck or lung
Persons who have had a gastrectomy or jejunoileal bypass
Persons who weigh less than 90% of their ideal body weight
Persons who smoke cigarettes or abuse drugs or alcohol
Populations defined locally as having an increased incidence of active TB disease, possibly including medically underserved or low-income populations
The T-SPOT.TB is the only IGRA, or TB blood test, without a warning or limitation in their package insert for screening immunocompromised individuals10,11
The reliability of the T-SPOT.TB test design, which includes washing and standardizing the number of cells in each patient specimen, is
supported by clinical data obtained even in challenging patient populations. The cell
enumeration technology in the proprietary T-SPOT.TB test therefore will allow clinicians to confidently screen and detect TB infection.14
Patient populations can vary, but your TB blood test results should not. The T-SPOT.TB test is accurate across all patient populations. In fact, the T-SPOT.TB test is the only TB blood test without a warning in their package insert against use the immunocompromised population.
Accurate across patient populations14
Highest sensitivity and specificity compared to other IGRAs
US-FDA approved borderline zone provides increased test resolution for results around the cut-off point16,17
Alatab et al, GBD 2017 Inflammatory Bowel Disease Collaborators. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2017 Oct; Volume 5, Issue 1, P17-30. DOI: https://doi.org/10.1016/S2468-1253(19)30333-4
Lai CC, Tan CK,et al. Diagnostic performance of whole-blood interferon-γ assay and enzyme-linked immunospot assay for active tuberculosis. J Microbiol Immunol Infect. 2011 Oct;44(5):406-7. doi: 10.1016/j.jmii.2011.07.002. Epub 2011 Sep 8.
Qiagen. QuantiFERON-TB Gold Plus (QFT-Plus) ELISA Package Insert. 1095849 Rev. 06. November 2019.
Rego K, Pereira K, MacDougall J, Cruikshank W. Utility of the T-SPOT®.TB test’s borderline category to increase test resolution for results around the cut-off point. Tuberculosis. 2018;108:178-185. doi:10.1016/j.tube.2017.12.005.
Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K, IGRA Expert Committee, Centers for Disease Control and Prevention (CDC). Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection – United States, 2010. MMWR Recomm Rep. 2010;59(RR-5):1-25.
QFT is a registered trademark of The Qiagen Group.
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